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Does 111SKIN’s Exosome Face Lift Live Up to the Hype?

A four-week treatment with serum and mask that lifts, firms, and restores the skin overnight.

At 34, I’ve tried enough skincare to know when something feels different. Most serums and masks promise instant miracles, but few deliver beyond hydration or a fleeting glow. When 111SKIN introduced the Exosome Face Lift, a four-week at-home treatment designed to visibly lift and firm, I wanted to see if it could really bring professional-level results into my bathroom.

SKINCARE

The protocol consists of two steps: the Exosome Shot Serum and the Exosome Overnight Mask. Every evening, after cleansing, I applied three to four pumps of the serum across my face, neck, and décolletage. The first surprise was the tingling sensation, not unpleasant, but noticeable. That comes from microspicules derived from a freshwater sponge, tiny needle-like structures that create micro-channels in the skin. This mechanism allows the exosomes, bacterial ones, taken from probiotic strains, to penetrate more deeply. Dr. Yannis Alexandrides, founder of 111 Harley St., designed this delivery system to mimic the benefits of in-clinic microneedling without the downtime.

The second step, the Overnight Mask, felt restorative from the first application. Its texture is comforting yet active, sinking into the skin and staying put throughout the night. Key ingredients include milk thistle extract, which helps prevent “zombie” cells that slow down skin renewal, and Lespedeza Capitata plant extract, which works to reset the skin’s circadian rhythm for an anti-fatigue effect. Together, the serum and mask worked as a duo, one creating pathways for deeper infusion, the other repairing and rebuilding while I slept.

Results became noticeable in stages. After the first week, my skin looked brighter and more even in tone. By the second week, I noticed firmer texture along the jawline and a subtle tightening effect around the cheek area. The real transformation came by week four: my skin felt more elastic, fine lines around my mouth and eyes appeared softened, and there was a visible lift that wasn’t just imagined. Clinical tests report a 20% lift and a 23% increase in firmness after four weeks, and in my case, those numbers didn’t feel far-fetched.

What stood out to me was how advanced the science felt without compromising on comfort. Bacterial exosomes enhanced cell communication and collagen production without the ethical and regulatory issues linked to animal or human sources. Swiss Ice Wine Extract provided an immediate tightening that I could see within minutes of application, while lactobacillus ferment kept my skin balanced. This wasn’t skincare designed for superficial results; it felt regenerative, targeted, and intelligent.

I won’t pretend it’s the kind of product you absentmindedly slap on before bed. The regimen requires consistency, and you feel it working every night. But that’s part of its appeal. By the end of the month, I felt like I had undergone something closer to a professional treatment than a skincare routine. For anyone serious about lifting, tightening, and investing in visible anti-aging results, the Exosome Face Lift doesn’t just meet expectations, it resets them.

Written by Katarina Doric

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